It looks mild and not quite classic for lamotrigine rash, but it’s difficult from a picture. The rash subsided after her treatment with lamotrigine was discontinued. 0. I know everyone will say “see a physician”, but American healthcare is terrible and I work two jobs. In children, the risk of developing a life-threatening rash is one in 50. 8% in pediatric patients (2 to 17 years of age) and 0. Aperantly starting with a low dose helps prevent the rashes from starting. 5 daily 15 to 28 (2) 25 daily 29 to 42 (2) 25 twice daily 43 to 56 (2) 25 every morning and 50 at Jun 26, 2014 路 Uncommon, but maybe: Lamotrigine (lamictal) can (rarely) cause serious, even life-threatening, rashes, but these usually occur within 2 to 8 weeks of starting treatment, but very rarely can occur later. The medicine was working really well and was really helping my mental health as well. Mar 12, 2018 路 Lamotrigine rash Benign allergy or severe adverse reaction? Kverno, Karan PhD, PMHNP-BC; Beauvois, Lisa MSN, FNP-BC, PMHNP-BC; Dudley-Brown, Sharon PhD, FNP-BC Feb 17, 2020 路 Serious skin rashes: Lamotrigine can cause serious rashes requiring hospitalization and discontinuation of treatment. 8%. May 28, 2024 路 Lamictal Uses. Children 2-17 years of age who take lamotrigine are more likely to develop serious rashes than adults who take the medication. Reply. sleep problems (insomnia). 12. 馃檹 Feb 13, 2024 路 Lamotrigine (Lamictal, Lamictal XR) is a medication that treats certain types of seizures and bipolar 1 disorder. It should also bear mentioning that the discontinuation of lamotrigine may not prevent a rash from becoming life-threatening. At 5 weeks increase by 0. But there are some side effects that might happen over a long time. It was actually pretty scary, it was on my arms and my chest. 1097/JCP. Don't fuck around with it. However, some people do not develop the rash until months or even years after stopping treatment. Not All Mucosal Rashes After Lamotrigine Are Stevens-Johnson Syndrome: Case of Mycoplasma pneumoniae-Induced Rash and Mucositis and Review of Differential Diagnosis J Clin Psychopharmacol . 3% of adults and 1% of children; Stevens-Johnson syndrome hey all. After a few weeks he decided to re introduce the meds to me , to discern if it really was that or some other allergen in my INTRODUCTION. I know this comment is 10 years old but I just want to thank you for this post/advice. Sep 4, 2023 路 In a prospectively followed cohort of pediatric patients 2 to 17 years old, the incidence of serious rash was approximately 0. With valproic acid (age 2-12 yr) Initial: 0. com has one) to make sure the steroid isn't spiking the levels of Lamotrigine. Something like 10% of people who try Lamictal get a rash and only . 1 Within bipolar disorder, it has the most evidence for the treatment of depression based on several evidence-based guidelines. It’s not super red or itchy, but I’m still concerned. 1176/ajp. They can happen weeks to months after starting the medication. Going back on Lamotrigine/Lamictal after bad rash. Rashes associated with lamotrigine Abstract. People aged 65 years and older can be prescribed lamotrigine, but healthcare providers will typically start older patients with a low dose and monitor them carefully for side Lamotrigine is used alone or together with other medicines to help control certain types of seizures (eg, partial seizures, tonic-clonic seizures, or Lennox-Gastaut syndrome) in the treatment of epilepsy. Is it possible that this is the lamictal rash, or is it something else. The good news is that there is at least one recent study on pub med that looked at people who got a rash from Lamictal, but then stopped and restarted titrating slower. A case of 77-year-old man with AGEP 6 days after sertraline administration is observed. On re-exposure to the causative (or related) drug, skin lesions appear within 1–3 days. It explains the risks associated with Lamictal. 6 to 6. Apr 18, 2019 路 (24 year old man developed rash after 1 week and fever after 3 weeks of lamotrigine therapy [bilirubin 1. Find patient medical information for Lamictal ODT oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Aug 30, 2018 路 Lamotrigine (LTG) is an anticonvulsant approved by the Food and Drug Administration for Lennox-Gastaut syndrome, partial seizures, tonic-clonic seizures, and maintenance treatment in bipolar I disorder. take a higher starting dose of lamotrigine than Mood Instability : For individuals with bipolar disorder, missing a dose of Lamictal can lead to mood swings and increased episodes of mania or depression. The medication helps stabilize mood and prevent extreme shifts in emotions. Been on for a decade. The incidence has been linked to rapid titration and an interaction with valproic acid that can increase the level of LTG. Contact your care team right away if you notice fevers or flu-like symptoms with a rash. 08% to 0. Always read the medication guide given with your lamotrigine tablets. If you develop a stomach upset after taking Lamictal, taking it with food may help. It wasn’t a severe rash but I stopped taking it anyway as advised by the doc. For more information, learn about epilepsy or visit our resources section. I didn't get Johnson Stevens syndrome, but I had several rashes. 5. Tell your doctor if you have ever had: a rash or allergic reaction after taking another seizure medication; kidney or liver disease; Jun 29, 2006 路 The risk of rash is decreased by initiating lamotrigine at a low dose, and titrating slowly over several weeks. d. 2015. SERIOUS SKIN RASHES. This medication is also suggested for patients suffering from seizure issues such as epilepsy. Jul 1, 2021 路 Rechallenge with lamotrigine after initial rash Seizure , 4 ( 1 ) ( 1995 ) , pp. Pustular drug eruption can be induced by selective serotonin reuptake inhibitors – a group of new antidepressants. If you develop a rash while taking Lamotrigine you Jun 9, 2023 路 Lamictal rash is a side effect of the anti-seizure drug Lamictal, which contains a medication known as lamotrigine. 7 The risk of rash may increase if Aug 21, 2021 路 A rash is a common side effect of Lamictal. Providers often have difficulty discriminating between serious versus benign Feb 8, 2024 路 I've been on Lamictal for three years. com Aug 4, 2021 路 In addition, children taking lamotrigine experience a high rate (14%) of accidental injury, though accidental injury is not a common side effect among adults. We present the case of a 25-year-old woman with bipolar disorder who was unable to tolerate aripiprazole, ziprasidone, and lamotrigine. 100mg (I was informed) is the therapeutic dose. I developed a light rash all over my body (mainly my chest and torso) today. The rash is mild in most cases, but in rare instances, it can be life threatening. There is a range of various medicines which Experiences with epilepsy can vary greatly on an individual basis. Posted by u/mooducky - 9 votes and 8 comments Mar 31, 2023 路 Rarely, lamotrigine may cause a potentially fatal rash requiring immediate drug discontinuation. i've only experienced anxiety a few times since starting the medication. 1999 Dec;156 (12):2015-6. 8% in kids and 0. i. Life threatening rash: This drug can cause rare but serious rashes Lamictal is a drug that is classified in anticonvulsant medicine category. I’ve developed a rash on my forearm where my elbow is located. “Bottom line”: the rate of serious rash in this analysis is between 2 and 4 cases per 10,000 new users of lamotrigine (the manufacturer’s usual quoted rate is higher: 1 per 1,000). By the end of the night the rash had spread to my neck and I had called the doctor and she told me to immediately stop taking it I never took it again. Lamictal Rash (look at our pic) Tue, 09/04/2007 - 10:44. 15 mg/kg/day PO qDay or divided q12hr for 2 weeks, THEN. These side effects can increase the risk of falling. May be taken with or without food. 1% (13/ Evaluate patients who develop fever or rash promptly, and discontinue lamotrigine if HLH or another serious immune-related adverse reaction is suspected and an alternative etiology for the signs In children with a rash attributed to another AED, 18. 8% in pediatric patients (aged 2 to 17 years) and 0. Sep 1, 2018 路 In the first 150 young people (5-19 years old) treated with lamotrigine in a special centre for epilepsy, seven developed a mild rash soon after starting the drug. Shaking or tremors. 1 mg /day total daily dose, after periods ranging from 47 to 236 days. A Lamictal rash can produce severe lifelong scars and death. Topic: Parents & Caregivers. I’m trying to get off of 200mg. Get it checked by a doctor, now! If you're getting it at 50mg it's best to speak up. 5 years). The rash may be red or purple and then turn into blisters or peeling of the skin. As someone who has recently been put on lamictal, I had all the typical worries. 01% of those actually develop the severe form of the rash. Dec 1, 1999 路 Mr. Jul 25, 2022 路 It is important to seek medical advice as soon as you experience a rash after taking Lamictal. This is followed by the skin peeling in concentric circles. Rashes more than a couple of months in, without a dose change, would be unusual. I’m Chris Aiken May 20, 2022 路 Many people can take lamotrigine safely for several months or years. I was expecting the worst, but it was totally fine. During pregnancy Also use an interaction checker (drugs. however, it's been becoming more regular the past two weeks. After this, your doctor may gradually increase your dose as needed. Feb 12, 2023 路 The incidence of serious rash associated with hospitalization and discontinuation of immediate-release lamotrigine in a prospectively followed cohort of pediatric patients (aged 2 to 16 years) with epilepsy receiving adjunctive therapy with immediate-release lamotrigine was approximately 0. Six months later, she developed an acute maculopapular rash with itching. In half (48%) of the cases of rash, LTG was coadministered with valproic acid There were seven case reports of seizure aggravation (see online supplementary table S3). The day before the rash appeared, she had been exposed to the light of a solarium. . 1016/s1059-1311(05)80082-2 View PDF View article View in Scopus Google Scholar Jan 1, 2021 路 Rashes Lamotrigine’s only serious risk is Stevens-Johnson syndrome, which can be fatal if left untreated. 3% in adults receiving Lamotrigine. Lamotrigine (LTG) is associated with the potential for a life-threatening rash (eg, Stevens-Johnson syndrome or toxic epidermal necrolysis). He received lamotrigine, 25 mg t. 3% to 0. Tips. 3% in adults. Patient education should include continuous monitoring of the rash for improvement after discontinuing the medication. Safety and efficacy has not been established. They were terribly itching and painful, a pair of them even surrounded by bruises. For psychiatric disorders, this may modulate reuptake of serotonin (5-HT) and may block reuptake of dopamine (DA) It is also thought to stabilize neuronal membranes and inhibit the release of excitatory May 30, 2023 路 Rashes can happen anytime during Lamictal treatment but are more likely within 2–8 weeks of starting the drug. Jul 29, 2022 路 WARNING. It was possible to re-introduce the lamotrigine without recurrence of persistent rash and without any TABLE 1: Recommended titration for rechallenge of lamotrigine Days (Weeks) Dose, mg 1 to 14 (2) 12. the feeling has been the same as the anxiety i had before beginning the medication. Lamictal Rash. , coadministrated with haloperidol, 20 mg b. On the first occasion, a morbilliform rash usually appears 1–2 weeks after starting the drug, but it may occur up to 1 week after stopping it. Seniors. Not to discount anyone else’s experience but just wanted to give a different account. Always read the medication guide given with Lamictal. 2 - 5 One major Jun 12, 2015 路 The period of onset of rash after start of LTG treatment varied between 1 day and 103 weeks, with the median duration of onset of 25 days (IQR: 14–35 days). Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with lamotrigine and each time you refill your prescription. The rate in several other commonly used antiseizure medications is somewhat lower, except for Dilantin. Possible side effects include dizziness, blurry or double vision, and headache. See full list on healthline. like the title says i've been on lamictal for 2+ years. 01 percent [5]. Apr 5, 2023 路 Rarely, Lamictal may cause a potentially fatal rash requiring immediate drug discontinuation. The rash is more common after increasing lamotrigine but it can happen at any time. What might help Call your doctor right away if you develop symptoms of a drug Sep 4, 2023 路 In a prospectively followed cohort of pediatric patients 2 to 17 years old, the incidence of serious rash was approximately 0. Apr 14, 2021 路 Lamotrigine oral tablet is a prescription medication used to treat seizures in people with epilepsy and bipolar disorder. These common side effects of lamotrigine may happen in more than 1 in 10 people. The past 2 weeks I have been dealing with a living hell of Hives that I cannot find any cause of. 5 mg daily. I would try to get it examined as soon as possible by a psychiatrist or dermatologist (hard to see quickly!) for safety. The Feb 13, 2018 路 Rechallenge is a reasonable option for many patients who discontinued lamotrigine after a rash. Apr 25, 2018 路 fever or rash promptly, and discontinue lamotrigine if HLH or another serious immune-related In the 24 years since lamotrigine’s 1994 approval, FDA identified eight cases worldwide of My doctor increased my dosage to the proper level gradually because of the possibility of the rash. I am… May 20, 2022 路 Common side effects. Twelve infants had symptoms not related to prematurity, including feeding problems, persistent crying, gastrointestinal symptoms, icterus prolongatus and irritability. 3% in adults receiving lamotrigine. However, it's very unlikely that the rash develops into that. Experiences with epilepsy can vary greatly on an individual basis. Jul 1, 2024 路 Adults and children older than 13 years of age not taking valproic acid (Depakote®), carbamazepine (Tegretol®), phenobarbital (Luminal®), phenytoin (Dilantin®), or primidone (Mysoline®)—At first, 25 mg of lamotrigine once a day for 2 weeks, then 50 mg once a day for 2 weeks. 1–0. Lamictal is also used to control seizures in people with epilepsy. Man, I don't know what is wrong with Lamictal but it needs to be checked by some professionals again. For those 18 years and older, Lamictal is used for maintenance treatment of bipolar disorder to reduce the occurrence of mood episodes. 3 mg/kg/day PO qDay or divided q12hr for 2 weeks. Oct 4, 2020 路 The rash can start as a small red bump or patch on the skin that itches, burns, swells, and becomes large and blotchy. So it’s going to be a pain in the ass to visit a doctor. 1. dry mouth, nausea, vomiting, stomach pain, diarrhea; fever, sore throat, runny nose; drowsiness, tired feeling; back pain; or. Objectives: Lamotrigine (LTG) is a drug commonly used to treat epilepsy and can also be used to manage mood disorders, such as bipolar disorder. 3% (3 per 1,000) in adults on adjunctive therapy for Feb 15, 2023 路 The incidence of these rashes, which have included Stevens-Johnson syndrome, is approximately 0. I was taking Lamictal for around 6 weeks and when I jumped up to 100mg a day I developed a really bad rash. Here, we examine the adverse effects associated with long-term use of LTG for the Yes I got the rash on the first day of taking my medicine within a few hours of taking the pill. Go to the doctor ASAP. Topic: Medication Issues. If you notice "any" rashes during that timeframe, report them to the doctor immediately. This is not a complete list of side I reduced my dosage 3 weeks ago from 200 to 100 and I've been so itchy lately. However, there was not a substantial reduction observed in the rate of benign rashes, which has still remained between 8 and 11 percent [6]. For children age 2 and older, it's often prescribed together with another anticonvulsant medication, but it may be used alone Skin rash is a common adverse effect of lamotrigine (LTG) in both add-on and monotherapy trials and is also the most common adverse event causing LTG withdrawal. Six months later, her dose was successfuly in- creased to 75 mg b. They were able to get avoid the rash. . It is very rare for a drug that has been taken for months or years to cause a morbilliform drug eruption. Feeling drowsy, sleepy or dizzy. Reduced Effectiveness : Consistency is Sep 19, 2014 路 6. From our series of 254 prospectively registered adult patients treated with LTG at a dosage of 25-100 mg/ day, the incidence of allergic and non-allergic skin reactions was 5. I've been on lamictal for almost 5 years. Stevens–Johnson Syndrome (SJS), a dermatological emergency is a rare condition; with a reported incidence of around 2. A, a 42-year-old man with a diagnosis of schizoaffective disorder, bipolar type, was hospitalized in our clinic after a recurrence of his disorder that was induced by discontinuing his drug therapy. There have been reports of osteoporosis and osteopenia, which increase your risk of breaking a bone. 156. Oct 24, 2023 路 Lamictal may cause a severe or life-threatening skin rash, especially in children and in people who take a very high starting dose, or those who also take valproic acid (Depakene) or divalproex (Depakote). Hence, use of lamotrigine is not indicated in children under 16 years of age. Other lamotrigine side effects may be more serious, including severe rashes, irregular heart rhythm Rash after years of being on lamictal. Abstract. Tell your doctor if you have ever had: a rash or allergic reaction after taking another seizure medication; kidney or liver disease; Stopped Lamictal cold turkey at the request of the Pharmacy after calling, and within 3 days all my symptoms were gone and the rash started healing. 4). Conclusions: Based on this retrospective analysis, a history of another AED-related rash is the greatest risk factor for developing rash to LTG; age younger than 13 years is also a risk factor. In a prospectively followed cohort of patients 2 to 16 years old (n=1983), 1 rash-related death occurred in a patient with epilepsy taking this drug as adjunctive therapy. In fact, Lamictal has a boxed warning about serious skin rashes. Her lamotrigine dose was titrated gradually within 1 month up to 100 mg b. 7 mg/dL, ALT 130 U/L, Alk P 274 U/L], resolving within 3 weeks on intravenous methylprednisolone; review of rates of rash in clinical trials of lamotrigine found reports of rash in 0. How is Lamictal rash treated? A mild Lamictal rash may go away on its own after your body adjusts to the new medication. I tapered from 200 to 150 after about 8 years of use and I didn’t feel anything. Urticarial rashes have also been observed in individuals who have taken other antidepressants with lesions typically appearing 1-14 days after initiation. That could cause a rash. I’ve been on lamictal for over 3 years and I’ve never gotten a rash on it. It looked like bad poison ivy. Am J Psychiatry. If you develop a stomach upset after taking lamotrigine, taking it with food may help. Mon, 07/14/2008 - 21:05. I feel like I'm having an allergic reaction to something, but I have not changed any products in my life and it's full body. There are things you can do to help you cope: Headaches. It's just not worth the risk. I was on lamotrigine for about 6 weeks, titrating up at a normal pace. Sleepiness and nausea and vomiting may also occur. I took me 2 or 3 months of gradual dosage increases to get to the proper dosage level. 1 cases per million people per year with a mortality rate of around 5%. Although, maybe if you titrate up slower it could help. 8% (16 of 1,983). Signs of a serious rash include: Older adults may be more sensitive to the side effects of this drug, especially dizziness, loss of coordination, or fainting. Diarrhoea. 9, 12, 13 Although most case reports involving LTG rechallenge use a slower titration, 14 - 17 this is not always followed in clinical practice. 33F, 43 kg, 165 cm, currently on lamictal, duration of the rash 5 months. 9. One of the most dangerous adverse effects of LTG is skin rash, which can make early cessation necessary. 8% (8 per 1,000) in pediatric patients (aged 2 to 16 years) receiving LAMICTAL as adjunctive therapy for epilepsy and 0. 2% experienced LTG-rash, whereas in adults without a rash from another AED, 3% experienced LTG-rash. (almost exactly 2. My understanding is that rashes from Johnson Stevens Syndrome will show up in the first three months after starting the drug, and it's pretty rare. 5 weeks (range 1 to 44 weeks). without reappearance of the rash. Difficulty sleeping. 2024 Mar 26. Skipping a dose can disrupt this balance and result in mood instability. One rash-related death was reported in a prospectively followed cohort of 1,983 pediatric patients (aged 2 to 16 years) with epilepsy taking Sep 1, 2018 路 Abstract. This medicine cannot cure epilepsy and will only work to control seizures for as long as you continue to take it. 1 SJS is named after two American pediatricians, Albert Mason Stevens and Frank Chambliss Johnson, who jointly published the first description of the disorder in the American Journal I have been taking lamictal for 22 years now. One rash-related death was reported in a prospectively followed cohort of 1,983 pediatric patients (aged 2 to 16 years) with epilepsy taking Aug 30, 2018 路 If a patient is rechallenged with LTG, it is recommended to wait at least 4 weeks, and the recommended starting dose ranges from 5 mg every 3 days to 12. 3 mg/kg q1-2Week to maintenance dose of 1-5 mg/kg/day PO qDay or divided q12hr; not to exceed 200 mg/day. Slow titration reduces this risk from 1 in 100 to about 1 in 2,500, but it does not lower the risk of benign rashes, which is quite high at 10% (Bloom R et al, An Bras Dermatol 2017;92(1):139–141). Feb 13, 2023 路 Nearly all cases of a rash occur 2 to 8 weeks after the initiation of lamotrigine. The rash ranges from a mild annoyance to a possibly life threatening Mar 1, 1995 路 Her GP was informed to esca- Rechallenge with lamotrigine after Initial rash late the daily dose by 25 mg every 2 weeks to a maximum dose of 200 mg daily but to discon- tinue the lamotrigine if she developed a rash. Hello, (21F) started lamictal November 2021. Published On: 10/24/22. Duration: 17 minutes, 27 seconds. doi: 10. Doubling the FDA recommended titration schedule for adult bipolar disorder may decrease the risk of rash in adolescents ( Tables 4 and and5), 5 ), as also recommended in the Connor and Meltzer text (2006) . Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms. Aggression, or feeling irritable or agitated. Lamotrigine-induced rash after sun exposure. It explains the risks associated with Oct 9, 2023 路 Lamotrigine may cause a severe or life-threatening skin rash, especially in children and in people who take a very high starting dose, or those who also take valproic acid (Depakene) or divalproex (Depakote). Chris Aiken: Welcome to the Carlat Psychiatry Podcast, keeping psychiatry honest since 2003. The incidence of these rashes, which have included Stevens-Johnson syndrome, is approximately 0. LAMICTAL® can cause serious rashes requiring hospitalization and discontinuation of treatment. The risk of getting a serious, life-threatening skin rash may also be higher if you: take lamotrigine while taking valproate [Depakene (valproic acid) or Depakote (divalproex sodium)]. The lamotrigine was stopped immediately when the rash was identified and was subsequently re-introduced, using a special very-low-dose-escalation regime, starting with 0. Please contact your doctor or medical team if you have any questions about your situation. Providers often have difficulty discriminating between serious versus benign rashes, and the package insert recommends Apr 22, 2014 路 Two cases of this severe skin condition were noticed after administration of amoxapine – tetracyclic antidepressant [25, 26]. Oct 24, 2022 路 How to assess, treat, and when you can restart after a lamotrigine rash. 0000000000001857. Among the 85 published cases of lamotrigine rechallenge, none developed Stevens Johnson syndrome; however, 10% to 15% developed a second rash. It's so weird. Rashes associated with lamotrigine May 5, 2023 路 Children and teenagers 2 to 17 years of age have a higher chance of getting a serious skin rash with lamotrigine. 3% in adults receiving LAMICTAL. His dose of lamotrigine was titrated gradually within a So I’ve been on a steady dose of lamotrigine for a while but there was an increase in dosage and that led to a sudden rash in places. 2,7 That risk is lessened by retitrating very slowly and waiting at least 4 weeks before reintroducing Mar 9, 2023 路 Mechanism of Action. Prescribers should assess the need for escalation to maintenance dose when restarting Lamictal in patients who have discontinued Lamictal for any reason, since the risk of serious rash is associated with high initial doses and exceeding the recommended dose escalation for lamotrigine (see section 4. Feb 1, 2015 路 Since the introduction of a gradual titration schedule in 1994, the rate of severe rashes with LTG has declined from 1 to 0. Transcript: Today, the fourth psychopharm commandment: Always stop lamotrigine after an initial rash. After reading your post, it felt informative and made me feel all warm, cozy and safe! <3 Hope all is well for you in these present DAYS. Aug 30, 2018 路 Lamotrigine (LTG) is associated with the potential for a life-threatening rash (eg, Stevens-Johnson syndrome or toxic epidermal necrolysis). So maybe if you go slow it’ll be ok. 67 - 71 , 10. This drug is often prescribed by doctors to improve anomalous mood in patients affected with mood disorders like bipolar disorder. Lamotrigine blocks the α subunit of voltage-sensitive sodium channels (VSNaC), which inhibits the release of glutamate. Sep 26, 2021 路 Bupropion-associated urticaria is an infrequent adverse reaction, and the estimated incidence is between 1% and 2% with an age and sex predilection favoring men less than 40 years of age. Oct 15, 2023 路 The mean maternal lamotrigine dosage was 304 mg/day (range 25 to 1150 mg/day), the mean follow up time after birth was 11. The rash may also appear after a few days of taking the medicine. My rash stopped getting worse about 24 hours after my last dose and then slowly improved. A rash that occurs in the first five days of taking lamotrigine is probably nondrug related but regardless, the patient should stop taking the drug and contact their doctor or psychiatrist as it may still represent a lamotrigine (hypersensitivity-type) reaction with potential internal organ involvement. Never had skin problems on it until November, when suddenly, in the space of a single day, I got blisters all over my legs. He gave me all the warnings about the rash and to stop taking it if I develop one. Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and life-threatening delayed drug hypersensitivity reaction characterized by skin eruption, fever, lymphadenopathies, and visceral involvement. Risk of serious (eg stevens johnson syndrome) is roughly 0. She was given extended-release VPA as a trial and developed AHS with a generalized rash, fever, liver and kidney involvement, and eosinophilia one week after the initiation of treatment. Here, we are presenting a 12 year old boy, who developed rare but life threatening DRESS syndrome due to Lamotrigine.
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